Introduction

Safe to say, you cannot have aesthetics without regeneration, the key to rejuvenation. Take that back another step, you cannot have regeneration without cell death, the deterioration of cells in a structured fashion.

But when you have senescence, a situation where neither death nor life can proceed in a correct way, you can’t have correct cell death, so you can’t have good regeneration. The fundamentals of senescence and the science of it… As it applies in the world of aesthetics is described here.

Disclaimers

This is for the purpose of education. Yes, I have Introduced an aesthetic arm to my medical practice. But my purpose here is to educate, not to pitch. Heavy opinion and speculation here and there as this is not a peer reviewed blog.

Discussion

It is well-established that stem cells from our bodies or from outside sources can go to tissues in need of repair automatically and can also, automatically, tell those tissues what to do to fix themselves in processes loosely known as regeneration. Well the big news now is the role of stem cells in the world of degeneration.

Degeneration and death, processes primarily governed by cells called senescent cells, are also affected by stem cells. Briefly, senescent cells are degenerating cells that don’t want to die but don’t want to be active.

Their campaign is uselessness: don’t live in function, but don’t die either. So, it turns out, the more senescent cells there are, the harder it is for regeneration to occur. And, the same way that stem cells talk to other cells to spread their campaign of regeneration by using exosomes (little vesicles secreted by cells that allow cells to communicate their message), senescent cells also use exosomes to spread their campaign of uselessness.

Well the really exciting news is that stem cells, in addition to their huge roles in regeneration, also clear our bodies of senescent cells! Yes. Stem cells also reduce degeneration, or aging, the end products of inflammation.

Adding to a long growing list of functions in tissue regeneration we are discovering, stem cells also clear the body of senescent cells! Consistent with this, as stem cells decrease in function and numbers in our body, senescent cells linger on uncleared as our stem cells diminish – – adding speed to the aging process in its later phases.

Big Pharma Steps

In In summary, it’s been a hard decade for stem cells. When they first appeared on the scene, they were quickly divided into 2 groups – ‘embryonic stem cells’ derived from rejected fetuses that big Pharma is still allowed to manipulate these embryonic stem cells in an effort to reduce their harm as they try to find uses for them (in primarily cancer research); and ‘adult stem cells’ that occur in all of us post birth that safely help us regenerate tissues plus reduce degeneration.

Since they were new, this past decade, stem cells were only given the really tough and chronic cases – and thus it seemed that they had limited value. And since they were new, they might have well been called scam cells because nobody believed in them. At least they were safe.

But, soon enough fortunately, we have realized that they worked – as do their information containing secretions called exosomes. Exosomes are tiny vesicles that cells spit in order to communicate with surrounding cells.

Stem cells and senescent cells as well all secrete, spit, fire off exosomes to spread their plan, tell surrounding cells what to do, recruiting their neighbors into their cause. As a result of this fascination with this relatively new found function of the stem cell, Big Pharma created a new term which is of greater importance to them than the stem cells that led to it! SASP – senescence associated secretory phenotype.

This becomes the big focus of big Pharma today. If skin is one of those organs, then the phenotype of its ideal organ function is beauty. It has to look good, feel good, to prove that it functions well.

Stem cells help the skin like they help any other organ, and it’s called aesthetics. They are drawn to inflammation and bring regeneration and a plan for exactly what to do. And it wasn’t bad enough that these senescent cells make regeneration harder, they have the property of being able to pass on their senescent quality to cells surrounding them. In fact, senescence can spread like an infectious disease almost because senescent cells can impart a senescent signal to cells that surround them, a little bit like zombies do in the movies.

So, stem cells have work to do there by clearing the senescent cells. Stem cells are involved thus in multiple processes of anti-aging, so regeneration and rejuvenation on the building side when drawn automatically by inflammatory markers, but also restoration on the maintenance side by killing zombie (senescent) cells (essentially produced by inflammation) that just won’t go on to die.

Xenolytics are the artificial products designed to mimic stem cell secretions the body uses for terminating senescent cells by communication the signal to go on and just die already and stop recruiting cells to their death defying senescent state.

So, there is regenerative properties for stem cells in there is the xenolytic property of stem cells. There’s actually a third way that stem cells promote restoration of tissue function. And that involves again and interaction which senescent cells.

And that is, they can reprogram senescent cells to not only go on die, but actually to no longer be senescence. Stem cells in effect undo the SASP secretory phenomena of the senescent cells. And sure enough, big Pharma has also keyed in to this reprogramming function of stem cells.

They are trying to mimic that function by studying how skin cells impart that reprogramming to senescent cells. And that reprogramming is basically on the undoing of the SASP.

And Big Pharma wants to do this by altering the genetic function of senescent cells by reprogramming the cells with artificial substances. If that doesn’t sound about it’s unnatural as you can get, I don’t know what does. So, by altering genetic expression profiles, big Pharma wants to undo the senescent process by reprogramming yourself.

All in attempt to mimic how stem cells shut down or at least compensate for senescent cells. Imitating nature has always been Big Pharma’s way. But when it starts happening at a cellular level in a world of anti-aging endorsed by the federal government in favor of natural processes, can you just start wondering where our priorities went.

No, not going to lose you. But my points: getting a good handle on senescence will allow you to intuit and incorporate good programs for aesthetics in your life. And once you know the good programs to choose from, you will choose what’s best for you. That is based on your goals, age, and expectations.

Bottom line is, pretty is cool. But realizing that regeneration must follow pretty lets you realize that the whole focus here is maintenance. Maintenance prevents excessive degeneration.

Maintenance and upkeep come from establishing goals, then sticking to them or at least not losing them too quickly. And maintenance keeps you one step ahead of senescence.

We have learned a great deal more about the way deterioration works in our bodies it in the past decade than we have in the previous century. These are exciting times. And as a result, our most elaborate campaigns for preventing it or at least working with it have become very effective. But first, we need to get a strong handle on how normal regeneration works.

Conclusion

So that’s how the body does it. And that’s how medical aesthetics can produce restoration and rejuvenation using stem cells, and makes you look better longer. So…. Yes, yet another use of stem cells.

Anti-aging in a formal sense. Medically because it’s helping the skin. But actual longevity if you’ve considered central deployment instead of local care. So, stem cells could perhaps turn out to be the most powerful way of making you look good and youthful longer.

And that’s by their abilities in removing the worn-out cells of the body. And not only does removing worn out cells makes you look more youthful; it actually makes you live longer. And as such the antiaging indication for stem cells is completely acceptable. And that is called frailty.

Sure enough, there are also artificial agents that can help us remove worn out cells from the body. And of course, a term has been coined for them, Xenolytics. And, sure enough, even if we get assistance removing worn out sells by the Xenolytics, we not only look younger, but we live longer.

So, Xenolytics, in more than one way, are our antiaging friends. As stated above, the more senescent cells, the more difficult it is to achieve rejuvenation. Stem cells are what the body uses to minimize the numbers of senescent cells.

So, stem cells, our own or from outside donor sources (umbilical sources), find tissues in need, and fix those tissues by telling them what to do – but they also have a role clearing their senescence cells that arose from inflammatory processes.

Science has confirmed that you take worn-out cells from the body, it lives longer. Using reliable markers and staining, senescent cells have been identified that are worn out cells that don’t want to go onto apoptosis (normal cell death), yet don’t want to leave normal functioning lives.

Furthermore, science confirms that these senescent cells can pass on this zombie trait to cells around them. The body uses stem cells to eliminate these senescent cells, thereby promoting anti-aging within the body.

We can achieve improved anti-aging results by deploying extra stem cells from allogenic sources outside the body (umbilical sources) or by extracting them from our own fat. Also, we can achieve similar senescent cell clearly effects using substances called Xenolytics.

In addition to improving clearing of senescent cells using increased stem cell numbers, we can probably take measures to prevent the formation of senescent cells by minimizing inflammation.

And once inflammation occurs, we can reduce it by using cryo-chambers. And essentially every time we say live longer, we are also staying organs function better. And when it comes to the skin, an organ, we are saying looks prettier.

Stay well,

DAVID ALLINGHAM, M.D., MS

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